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2024
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Industry New Knowledge | Light Curing DLP 3D Printing Fe @ BT/HA Piezoelectric Ceramic Bracket.
Author:
Recently, a team led by Guomin Wu (M.D.) from Jilin University published a paper titled The Electrical Properties and In Vitro Osteogenic Properties of 3D-Printed Fe@BT/HA Piezoelectric Ceramic Scaffold，The preparation of iron doped barium titanate/hydroxyapatite ceramics by DLP 3D printing and its effect on electrical properties and bone formation ability were discussed.
Original link: https://doi.org/10.1016/j.ceramint. 2024.06.371
Adventure Technology official website: http://www.adventuretech.cn/
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research content
Bone defect is a common clinical problem caused by trauma, infection, tumor or osteonecrosis.In the treatment of bone defects, autologous bone graft is considered to be the "gold standard" for the treatment of bone defects, which provides a scaffold for bone regeneration in the damaged area. however,Autogenous bone grafting has many limitations, such as complications at the donor site, limited bone sources, and surgical complexity.
Researchers find natural human bone has piezoelectric effect(piezoelectricity), that is, when the bone tissue is subjected to mechanical force, it will produce electrical stimulation,Contribute to the regeneration of bone tissue. Therefore, a variety of lead-free piezoelectric materials have been developed, among which barium titanate (BT) and hydroxyapatite (HA) composites show good potential. Hydroxyapatite is known for its good biocompatibility and properties of promoting bone cell adhesion and proliferation, while barium titanate is able to generate electrical stimulation under physiological load, thereby enhancing bone cell growth and differentiation.
This study was designed to evaluate the effects of different contents of iron (Fe) on electrical properties and in vitro osteogenic performance by incorporating different contents of iron (Fe) into barium titanate/hydroxyapatite (BT/HA) system. Specific objectives include:
electrical performance testBy adding Fe element, the piezoelectric effect of BT/HA composites is improved and the electrical properties of the materials are enhanced.
Evaluation of osteogenic performance: To investigate the effect of Fe on bone regeneration, and to analyze the effect of Fe content on the proliferation and differentiation of bone marrow mesenchymal stem cells (DPSCs).
optimizing doping content: To find the best balance between Fe content and osteogenic and electrical properties.
- 1, SEM and EDS images of different ceramic samples.
2, XRD patterns of different ceramic samples.
3, Electrical results of different piezoceramic samples.
4, In vitro biosafety and osteogenic properties of different ceramic samples.
Conclusion
In this study, the effect of Fe on the electrical properties and in vitro osteogenesis of the material was explored by adding different contents of Fe into the barium titanate/hydroxyapatite (BT/HA) system. The results show that Fe incorporation has a dual effect on the electrical and osteogenic properties: the appropriate amount of Fe can enhance the electrical properties of the material and promote the regeneration of bone tissue, but too much Fe may adversely affect these properties. The results of the study determined that 1.0wt% Fe is the optimal amount of incorporation, which provides a theoretical basis for the further development of piezoelectric ceramic materials for bone tissue engineering.
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